
Research Interests:
- Role of Inflammasome-mediated neuroinflammation in the neuropathogenesis of HIV-infection and Alzheimer’s Disease.
- Use of CRISPR/Cas9 gene-editing technology targeting latent HIV infection in the brain.
- Use of nanotechnology-based drug delivery approaches targeting HIV infection in the brain and Alzheimer’s disease.
Scholarly Work:
Publications:
· Nagesh Kolishetti, Arti Vashist, Adriana Yndart Arias, Venkata Atluri, Shanta Dhar, and Madhavan Nair (2022). Recent advances, status, and opportunities of magneto-electric nanocarriers for biomedical applications. Molecular Aspects of Medicine, 83; 101046. https://doi.org/10.1016/j.mam.2021.101046
· Vashist A, Atluri V, Raymond A, Kaushik A, Parira T, Huang Z, Durygin A, Tomitaka A, Nikkhah-Moshaie R, Vashist A, Agudelo M, Chand H, Saytashev I, Ramella-Roman JC and Nair M (2020). Development of Multifunctional Biopolymeric Auto-Fluorescent Micro and Nanogels as a Platform for Biomedical Applications. Front. Bioeng. Biotechnol. 8:315. doi: 10.3389/fbioe.2020.00315.
· Atluri VSR, Tiwari S, Rodriguez M, Kaushik A, Yndart A, Kolishetti N, Yatham M, and Nair M (2020). Inhibition of Amyloid-Beta Production, Associated Neuroinflammation, and Histone Deacetylase 2-Mediated Epigenetic Modifications Prevent Neuropathology in Alzheimer’s Disease in vitro Model. Frontiers in Aging Neuroscience, 11:342. doi: 10.3389/fnagi.2019.00342
· Sneham Tiwari, Venkata Atluri, Ajeet Kaushik, Adriana Yndart, Madhavan Nair. 2019. Alzheimer’s disease: Pathogenesis, Diagnostics, and Therapeutics. International Journal of Nanomedicine, 2019: 5541-5554.
· Ajeet Kaushik, Adriana Yndart, Venkata Atluri, Sneham Tiwari, Asahi Tomitaka, Purnima Gupta, Rahul Dev Jayant, David Alvarez‑Carbonell, Kamel Khalili, Madhavan Nair. 2019. Magnetically guided non-invasive CRISPR-Cas9/gRNA delivery across the blood-brain barrier to eradicate latent HIV-1 infection. Scientific Reports 9, 3928.
· Sneham Tiwari, Venkata Subba Rao Atluri, Adriana Yndart Arias, Rahul Dev Jayant, Ajeet Kaushik, Jonathan D Geiger, and Madhavan N Nair. 2018. Withaferin A suppresses Beta-amyloid in APP expressing cells: Studies for Tat and Cocaine associated neurological dysfunctions. Frontiers in Aging Neuroscience 10.
· Jayant, R.D., Tiwari, S., Atluri, V., Kaushik, A., Tomitaka, A., Yndart, A., Colon-Perez, L., Febo, M., and Nair, M. 2018. Multifunctional Nanotherapeutics for the Treatment of neuroAIDS in Drug Abusers. Scientific Reports 8, 12991.
· Upal Roy, Vadym Drozd, Andriy Durygin, Jesse Rodr´ıguez, Paul Barber, Venkata Atluri, Xiaohua Liu, Thomas G Voss, Surendra Saxena, and Madhavan Nair. 2018. Characterization of Nanodiamond-based anti- HIV drug Delivery to the Brain. Scientific Reports 8; 1603. doi: 10.1038/s41598-017-16703-9.
· Thangavel Samikkannu, Carmen T. Mulet, Venkata Atluri, Marisela Agudelo, Rhonda Rosenberg, Jessy G. Devieux, and Madhavan Nair. 2018. Oxidative Stress in HIV infection and alcohol use: Role of redox signals in the modulation of lipid rafts and ABC-transporters. Antioxidants and Redox Signaling, 28(4): 324-337.
· Venkata S R Atluri*., Rahul Dev Jayant*., Sneham Tiwari., Sudheesh Pilakka Kanthikeel., Ajeet Kaushik., Adriana Yndart and Madhavan Nair. 2017. Novel nanoformulation to mitigate co-effects of drugs of abuse and HIV-1 infection: Towards the treatment of NeuroAIDS. J Neurovirol. 2017 Jul 31. doi: 10.1007/s13365-017-0538-8. *Equal First Author Contribution.
· Vidya Sagar., Sudheesh Pilakka Kanthikeel., Paola C. Martinez., V S R Atluri, and Madhavan Nair. 2017. Common gene-network signature of different neurological disorders and their potential implications to neuroAIDS. PLoS One. 2017 Aug 8; 12(8): e0181642. doi: 10.1371/journal.pone.0181642.
· Ajeet Kaushik, Roozbeh Nikkhah-Moshaie, Raju Sinha, Vinay Bhardwaj, Venkata Atluri, Rahul Jayant, Adriana Yndart, Babak Kateb, Nezih Pala, and Madhavan Nair. 2017. Investigation of ac-magnetic field stimulated nano electroporation of magneto-electric nano-drug-carrier inside CNS cells. Scientific Reports,7: 5663. doi:10.1038/srep45663.
· Venkata SR Atluri, Rahul Dev Jayant, Sudheesh Pilakka Kanthikeel, Gabriella Garcia, Samikkannu Thangavel, Adriana Yndart, Ajeet Kaushik, and Madhavan Nair. 2016. Development of TIMP1 magnetic nanoformulation for the regulation of synaptic plasticity HIV-1 infection. International Journal of Nanomedicine. doi: 10.2147/IJN.S108329.
· Samikkannu Thangavel., Venkata Atluri., Madhavan Nair. 2016. HIV and Cocaine Impact Glial Metabolism: Energy Sensor AMP-activated protein kinase Role in Mitochondrial Biogenesis and Epigenetic Remodeling. Scientific Reports, 6: 31784. doi: 10.1038/srep31784.
· Ajeet Kaushik, Venkata Atluri, Phani Kiran Vabbina, Pratikkumar Shah, Rahul Dev Jayant, Adriana Yandart, Madhavan Nair. 2016. Electrochemical monitoring-on-chip (E-MoC) of HIV infection in the presence of cocaine and therapeutics. Biosensors and Bioelectronics, 86: 426-431. doi: 10.1016/j.bios.2016.06.086.
· Sagar, V., Atluri, V.S.R., Kami, A., Shah, P., Nagasetti, A., Pilakka-Kanthikeel, S., El-Hage, N., McGoron, A., Takemura, Y. & Nair, M. 2016. Coupling of transient near-infrared photonic with magnetic nanoparticle for potential dissipation-free biomedical application in the brain. Scientific Reports, 6: 29792. doi:10.1038/srep29792.
· Venkata S Atluri, Sudheesh Pilakka-Kanthikeel, Gabriella Garcia, Rahul Dev Jayant, Vidya Sagar, Samikkannu Thangavel, Adriana Yndart, Madhavan Nair. 2016. Effect of Cocaine on HIV Infection and Inflammasome Gene Expression Profile in HIV Infected Macrophages. Scientific Reports, 6: 27864. doi:10.1038/srep27864.
· Marisela Agudelo, Gloria Figueroa, Adriana Yndart, Karla Munoz, Venkata Atluri, Samikkannu Thangavel, Madhavan P. Nair. 2016. Profile of Class I Histone Deacetylases (HDAC) by Human Dendritic Cells after Alcohol Consumption and in vitro Alcohol Treatment and their Implication in Oxidative Stress: Role of HDAC Inhibitors Trichostatin A and Mocetinostat. PLoS ONE 11(6): e0156421. doi:10.1371/journal.pone.0156421.
· Atluri, V.S.R*., Sagar, V*., Pilakka-Kanthikeel, S., & Nair, M. 2016. Magnetic nanotherapeutics for synaptic plasticity dysregulations during neuroAIDS and drug abuse. Molecular Brain, 9:57. DOI: 10.1186/s13041-016-0236-0. *Equal First Author Contribution.
· Rahul Dev Jayant, Daniela Sosa, Ajeet Kaushik, Venkata Atluri, Arti Vashist, Asahi Tomitaka, Madhavan Nair. 2016. Current status of non-viral gene therapy for CNS disorders. Expert Opinion on Drug Delivery. DOI:10.1080/17425247.2016.1188802.
· Ajeet Kaushik, Rahul D. Jayant, Roozbeh Nikkhah-Moshaie, Vinay Bhardwaj, Upal Roy, Zaohua Huang, Ariel Ruiz, Adriana Yndart, Venkata Atluri, Nazira El-Hage, Kamel Khalili, Madhavan Nair. 2016. Magnetically guided central nervous system delivery and toxicity evaluation of magneto-electric nanocarriers. Scientific Reports. 6:25309; DOI: 10.1038/srep25309.
· Venkata Subba Rao Atluri. 2016. Editorial: HIV and illicit drugs of abuse. Frontiers in Microbiology. 7:221. doi: 10.3389/fmicb.2016.00221.
· Venkata Subba Rao Atluri*, Kesava Rao Venkata Kurapati*, Samikkannu Thangavel, Gabriella Garcia, Madhavan Nair. 2016. Natural Products as Anti-HIV Agents and Role in HIV-Associated Neurocognitive Disorders (HAND): A Brief Overview. Frontiers in Microbiology, 6: 01444. doi: 10.3389/fmicb.2015.01444. *Equal First Author Contribution.
· Marisela Agudelo., Gloria Figueroa., Adriana Yndart., Gianna Casteleiro., Karla Muñoz., Thangavel Samikkannu., Venkata Subba Rao Atluri and Madhavan P. Nair. 2015. Alcohol and cannabinoids differentially affect HIV infection and the function of human monocyte-derived dendritic cells (MDDC). Frontiers in Microbiology, 6:1452. doi: 10.3389/fmicb.2015.01452.
· Venkata Atluri, Melissa Hidalgo, Samikkannu Thangavel, Kesava Rao Kurapati, Madhavan Nair. 2015. Synaptic plasticity and cognitive disorders in neurotropic viral infections. Neural Plasticity, Article ID: 138979, http://dx.doi.org/10.1155/2015/138979.
· Upal Roy, Hong Ding, Sudheesh Pilakka Kanthikeel, Andrea Raymond, Venkata Atluri, Adriana Yndart, Madhavan Nair. 2015. Preparation and characterization of anti-HIV nano-drug targeted to microfold cells of gut-associated lymphoid tissue. International Journal of Nanomedicine, 10: 5819-5835. PMID: 26425084.
· Venkateswara Reddy Gogulamudi, Mohan Lal Dubey, Deepak Kaul, Venkata Subba Rao Atluri, Rakesh Sehgal. 2015. Downregulation of the host tryptophan-aspartate-containing coat (TACO) gene restricts the entry and survival of Leishmania donovani in the human macrophage model. Frontiers in Microbiology, 6:946. doi: 10.3389/fmicb.2015.00946.
· Upal Roy, Venkata Atluri, Marisela Agudelo, Madhavan Nair. 2015. DJ1 Expression Downregulates in Neuroblastoma Cells (SK-N-MC) Chronically Exposed to HIV-1 and Cocaine. Frontiers in Microbiology, 6: 749. doi: 10.3389/fmicb.2015.00749. PMID: 26284039.
· Adriana Yndart, Ajeet Kaushik, Marisela Agudelo, Andrea Raymond, Venkata Atluri, Shailendra Saxena, and Mahdavan Nair. 2015. Investigation of Neuropathogenesis in HIV-1 Clade B and C Infection Associated with IL-33 and ST2 Regulation. ACS Chemical Neuroscience. 2015 Sep 16;6(9):1600-12. PMID: 26110635.
· Samikkannu T, Ranjith D, Rao KVK, Atluri VSR, Pimentel E, El-Hage N, Nair MPN. 2015. HIV-1 gp120 and morphine-induced oxidative stress: role in cell cycle regulation. Front. Microbiol. 6:614. doi: 10.3389/fmicb.2015.00614. PMID: 26157430.
· Sagar Vidya, Pilakka-Kanthikeel S, Atluri VSR, Ding H, Priestap H, Nair M.P. 2015. Therapeutical Neurotargeting via Magnetic Nanocarrier: Implications to Opiate-Induced Neuropathogenesis and NeuroAIDS. Journal of Biomedical Nanotechnology, 11: 1722-1733. PMID: 26502636.
· Samikkannu Thangavel, Kesava Rao Kurapati, Abdul Ajees Abdul Salam, Venkata Atluri, Elena Kaftanovskaya, Marisela Agudelo, Suray Perez, Andrea Raymond, Hong Ding, Madhavan Nair. 2015. HIV Subtypes B and C gp120 and Methamphetamine Interaction: Role of Dopaminergic System Implicates Differential Neuronal Toxicity. Scientific Reports. 5. Article number: 11130 doi:10.1038/srep11130. PMID: 26057350.
· Venkata Atluri, Melissa Hidalgo, Samikkannu Thangavel, Kesava Rao Kurapati, Rahul Jayant, Vidya Sagar, Madhavan Nair. 2015. Effect of human immunodeficiency virus on blood-brain barrier integrity and function: an update. Frontiers in Cellular Neuroscience, 9:212. doi: 10.3389/fncel.2015.00212. PMID: 26113810.
· Sudheesh PK, Andria Raymond, Venkata Subba Rao Atluri; Vidya Sagar, Shailendra Saxena, Patricia Diaz, Semithe Chevelon, Michael Concepcion, Madhavan Nair. 2015. Sterile alpha motif and histidine/aspartic acid domain-containing protein 1 (SAMHD1)-facilitated HIV restriction in astrocytes is regulated by miRNA- 181a. Journal of Neuroinflammation 2015, 12:66. PMID: 25890101.
· Venkata Atluri*, Melissa Hidalgo*, Madhavan Nair. 2015. Drugs of abuse in HIV infection and neurotoxicity. Frontiers in Microbiology, 6: 217. PMID: 25852673. *Equal First Author Contribution.
· Rahul Dev Jayant, Venkata Atluri, Marisela Agudelo, Vidya Sagar, Ajeet Kaushik, Madhavan Nair. 2015. Sustained Release NanoART Formulation for the Treatment of NeuroAIDS. International Journal of Nanomedicine, 10: 1077-1093. PMID: 25709433.
· Ajeet Kaushik, Adriana Yndrt, Rahul Dev Jayant, Vidya Sagar, Venkata Atluri, Shekhar Bhansali, Madhavan Nair. 2015. Electrochemical sensing method for point-of-care cortisol detection in HIV-infected patients. International Journal of Nanomedicine, 10: 677-685. PMID: 25632229.
· Samikkannu Thangavel, Venkata Atluri, Adriana Yndart, Kesava Rao Venkata Kurapati, Carmen T Mulet, Rahul Dev Jayant, Madhavan Nair. 2014. HIV-1 Subtypes B and C Tat Differentially Impact Synaptic Plasticity Expression and Implicates HIV-Associated Neurocognitive Disorder. Current HIV Research, 12(6), 397-405. PMID: 25613138.
· Kesava Rao Venkata Kurapati, Thangavel Samikkannu, Venkata Subba Rao Atluri, Elena Kaftanovskaya, Adriana Yndart, Madhavan P. N. Nair. 2014. β-Amyloid1-42, HIV-1Ba-L (Clade B) Infection and Drugs of Abuse Induced Degeneration in Human Neuronal Cells and Protective Effects of Ashwagandha (Withania somnifera) and Its Constituent Withanolide A. PLoS ONE, 9(11): e112818. doi: 10.1371/journal.pone.0112818. PMID: 25415340.
· Venkata Subba Rao Atluri, Kesava Rao Venkata Kurapati, Thangavel Samikkannu and Madhavan P.N. Nair. 2014. Biomarkers of HIV Associated Neurocognitive Disorders. JSM Biomarkers; 1(1): 1002.
· Venkata Subba Rao Atluri, Venkateswara Reddy Gogulamudi, Pratibha Singhi, Niranjan Khandelwal, Lakshmana Swamy Parasa, Nancy Malla. 2014. Pediatric neurocysticercosis: usefulness of antibody response in cytocidal treatment follow-up. BioMed Research International. Volume 2014, Article ID # 904046. http://dx.doi.org/10.1155/2014/904046. PMID: 25215297.
· Atluri, V.S.R., Pilakka-Kanthikeel, S., Samikkannu, T. et al. Vorinostat positively regulates synaptic plasticity genes expression and spine density in HIV infected neurons: role of nicotine in the progression of HIV-associated neurocognitive disorder. Mol Brain 7, 37 (2014). https://doi.org/10.1186/1756-6606-7-37.
· Samikkannu T, Rao KV, Pilakka Kanthikeel S, Venkata SR Atluri, Agudelo M, Roy U, Nair MP. 2014. Immunoneuropathogenesis of HIV-1 clades B and C: Role of redox expression and thiol modification. Free Radic Biol Med. 2014; 69:136-44. PMID: 24480751.
· Hong Ding, Vidya Sagar, Marisela Agudelo, Sudheesh Pilakka-Kanthikeel, Venkata Subba Rao Atluri, Andrea Raymond, Thangavel Samikkannu and Madhavan P Nair. 2014. Enhanced blood-brain barrier transmigration using a novel transferrin-embedded fluorescent magneto-liposome nanoformulation. Nanotechnology 25; 055101, doi:10.1088/0957-4484/25/5/055101. PMID: 24406534.
· Venkata Subba Rao Atluri, Thangavel Samikkannu, Kesava Rao Venkata Kurapati, Madhavan PN Nair. 2014. Commentary of Drugs of Abuse and HIV Infection in South Florida, USA. Austin Journal of Drug Abuse and Addiction. 05/2014; 1(1):3.
· Kurapati, V.K.R, Samikkannu T, Atluri, V.S.R, Nair, M.P.N. 2014. Cell Cycle Checkpoints and Pathogenesis of HIV-1 Infection: A Brief Overview. Journal of basic and clinical physiology and pharmacology. July 19, 2014, DOI: 10.1515/jbcpp-2014-0018. PMID: 25046311.
· Rakesh Guduru, Ping Liang, Carolyn D. Runowicz, Madhavan Nair, Venkata Atluri, Sakhrat Khizroev. 2013. Magneto-electric Nanoparticles to Enable Field-controlled High-Specificity Drug Delivery to Eradicate Ovarian Cancer Cells. Scientific Reports. 2013/10/16/online. doi: 10.1038/srep02953.
· Kurapati KRV, Atluri VSR, Samikkannu T, Nair MPN. 2013. Ashwagandha (Withania somnifera) Reverses β- Amyloid1-42 Induced Toxicity in Human Neuronal Cells: Implications in HIV-Associated Neurocognitive Disorders (HAND). PLoS ONE 8(10): e77624. doi: 10.1371/journal.pone.0077624.
· Venkata Subba Rao Atluri, Sudheesh P. Kanthikeel, Pichili VB Reddy, Adriana Yndart, Madhavan Nair. 2013. Human Synaptic Plasticity gene expression profile and dendritic spine density changes in HIV-infected human neuronal cells: Role in HIV-associated neurocognitive disorders. PLoS ONE 8(4): e61399. doi:10.1371/journal.pone.0061399.
· Sudheesh PK; Venkata Subba Rao Atluri, Vidya Sagar, Madhavan Nair. 2013. Targeted Brain Derived Neurotropic Factors (BDNF) Delivery across the Blood-Brain Barrier for Neuro-Protection Using Magnetic Nano Carriers: An In-Vitro Study. PLoS ONE 8(4): e62241. doi: 10.1371/journal.pone.0062241.
· Reddy PV, Agudelo M, Atluri VS, Nair MP. Inhibition of nuclear factor erythroid 2-related factor 2 exacerbates HIV-1 gp120-induced oxidative and inflammatory response: role in HIV associated neurocognitive disorder. Neurochem Res. 2012;37(8):1697-1706. doi:10.1007/s11064-012-0779-0
· Rita Mukhopadhyay., Goutam Mandal., Venkata Subba Rao Atluri., Katherine Figarella., Nestor L. Uzcategui., Yao Zhou., Eric Beitz., A. Abdul Ajees and Hiranmoy Bhattacharjee. 2011. The role of alanine 163 in solute permeability of Leishmania major aquaglyceroporin LmAQP1. Molecular and Biochemical Parasitology, 175(1): 83-90.
· Atluri, V.S.R., Singhi, P., Khandelwal, N., Malla, N. 2011. 2D-PAGE analysis of Taenia solium metacestode 10- 30 kDa antigens for the serodiagnosis of neurocysticercosis in children. Acta Tropica, 2011; 118(2): 165- 169.
· Sehgal R., Gogulamudi V. Reddy., Jaco J. Verweij., Atluri V. Subba Rao. 2010. Prevalence of intestinal parasitic infections among school children and pregnant women in a low socio-economic area, Chandigarh, North India. Reviews in Infection, 1(2): 100-103.
· Lakshmana swamy Parasa., Cyril Arun kumar., Sirisha Para., Venkata Subba Rao Atluri, K. Santhisree, P. Raja Kumar and C. Rattiah Setty. 2010. Epidemiological survey of methicillin-resistant Staphylococcus aureus in the community and hospital, Gannavaram, Andhra Pradesh, South India. Reviews in Infection, 1(2): 117-123.
· Atluri, V.S.R., Singhi, P., Khandelwal, N., Malla, N. 2009. Evaluation of excretory-secretory and 10-30 kDa antigens of T. solium Cysticerci by EITB assay for the diagnosis of neurocysticercosis. Parasite Immunology, 31(3): 151-5.
· Atluri, V.S.R., Singhi, P., Khandelwal, N., Malla, N. 2009. Neurocysticercosis immunodiagnosis using Taenia solium Cysticerci crude soluble extract, excretory-secretory and lower molecular mass antigens in serum and urine samples of Indian children. Acta Trop., 110(1):22-7.
Book chapters:
· Arti Vashist, Nagesh Kolishetti, Adriana Yndart Arias, Andrea D. Raymond, Atul Vashist, Sukanya Bhunia, Deborah Brooks, Venkata Atluri, and Madhavan Nair. 2024. Chapter 10: Recent updates on the emerging role of vegetable oils in the development of hydrogel technology for biomedical applications. Vegetable Oil-Based Polymers and Their Surface Applications. Publisher: Elsevier Inc. ISBN 978-0-12-822189-1. https://doi.org/10.1016/B978-0-12-822189-1.00014-3.
· Venkata Atluri, Ravi Doddapaneni, Eliset Perez. 2017. Personalized Therapeutics: First Take-Home Messages. Book Title: Advances in Personalized Nanotherapeutics. ISBN:978-3-319-63632-0. Publisher: Springer, Cham, doi: 10.1007/978-3-319-63633-7_2.
Conference Presentations:
· Sydney Sands, Vincent Tran, Hayden Evans, Elizabeth Sarkisian, Deirdre Kokasko, Rickey Shah, Ram Batta, Shelbi Salinas, Leah Kramer, Julie McGroarty, and Venkata Atluri. Role of NLRP3-Inflammasome-Mediated Inflammatory Response Induced by Amyloid Precursor Protein (APP695) and its Swedish Mutant in the Development of Alzheimer’s Disease. Noorda COM Research Symposium, 2024.
· Braydon Black, Nestor Cruz1, Bryan Jimenez, Trevor Moore, Scott Baker, and Venkata Atluri. Inflammasome Genes Expression in Alzheimer’s Disease Cell Culture Models and its Role in the Development of AD Pathology. Noorda COM Research Symposium, 2024.
· Sydney Sands, Bryan Jimenez, Vincent Tran, Hayden Evans, Trevor Moore, Braydon Black, Nestor Cruz, Elizabeth Sarkisian, and Venkata Atluri. 2024. Role of Amyloid Precursor Protein (APP695) and its Swedish Mutant in Inducing Inflammasome-Mediated Inflammatory Response in the Brain. Roseman University Research Symposium 2024, South Jordan, Utah.
· Venkata Atluri, Adriana Yndart, Nagesh Kolishetti, Arti Vashist, Alexandros Makriyannis, and Madhavan Nair. 2023. Anti-HIV and Anti-inflammasome Activity of a Novel Chiral Potent Endocannabinoid Ligand (R)- N-(1-Methyl-2-hydroxyethyl)-13-(S)-methyl-arachidonamide (AMG315). 19th International Symposium on NeuroVirology, Montreal, Quebec, Canada.
· Devin Pfister, Maria Avakova, Brooke Johnston, Joshua Hamm, Sean Donnelly, Sneham Tiwari, Prem Chapagain, Madhavan Nair, and Venkata Atluri. Therapeutic use of amyloid-beta and inflammasome-inhibitors to prevent the development of neuropathology in Alzheimer's disease. Roseman University Symposium, 2023.
· Devin Pfister, Maria Avakova, Brooke Johnston, Joshua Hamm, Sean Donnelly, Sneham Tiwari, Prem Chapagain, Madhavan Nair, and Venkata Atluri. Therapeutic use of amyloid-beta and inflammasome-inhibitors to prevent the development of neuropathology in Alzheimer's disease. Noorda COM Research Symposium, 2023.
· Sean Donnelly, Brooke Johnston, Devin Pfister, Victor M Jimenez, and Venkata S Atluri. Elimination of HIV-1 latency in the brain cells targeting HIV-1 Tat and LTR genes using a combination of CRISPR gene-editing and nanotechnology approaches. Noorda COM Research Symposium, 2022.
· Maria Avakova, Joshua Hamm, Kota Ramana, and Venkata S Atluri. Immunotherapy and nanotechnology combinatory approach for the treatment of Alzheimer’s Disease. Noorda COM Research Symposium, 2022.
· Kolishetti, N., Surnar, B., Shah, A., Ramirez-Jaime, R., Atluri, V., Arias, A. Y., Nair, M., and Dhar, S. “Combination therapy using brain accumulating polymeric nanoparticles for tackling HIV-infected brain reservoirs in drug abuse population” at TechConnect World 2021, in Washington DC October 18-20 2021.
· Kolishetti, N.; Surnar, B.; Shah, A.; Kamran, M. Z.; Royden, R.; Atluri, V.; Arias, A. Y.; Nair, M., and Dhar, S. “A Combination therapy using brain accumulating polymeric nanoparticles for tackling HIV-infected brain reservoirs in drug abuse population” at the ACS Spring Meeting 2021, United States, April 5, - April 30, 2021 (2021), POLY-. (Research Presentation).
· Ann Barral, Venkata Atluri, Sneham Tiwari, Melisa Rodriguez, Ajeet Kaushik, Adriana Yndart, Nagesh Kolishetti, Mohan Yatham, Madhavan Nair. Inhibition of Aβ production, associated neuroinflammation and HDAC2-mediated epigenetic modifications prevent neuropathology in Alzheimer’s disease. 6th Annual Personalized NanoMedicine Symposium - November 20th, 2019, Miami, FL.
· Cardenas, Chabeli., Rodriguez, Melisa., Yatham, Puja., Miller, Nicole., Atluri, Venkata., Nair, Madhavan. Therapeutic Use of Withaferin A and INF4E in Alzheimer’s Disease. F-STAR Summer Research Program Symposium, 2018, at FIU, Miami, FL.
· Venkata Atluri, Sneham Tiwari, Melisa Rodriguez, Puja Yatham, Adriana Yndart, Ajeet Kaushik, Purnima Gupta, and Madhavan Nair. Withaferin A and CRID3 inhibit neuropathology of Alzheimer’s disease: A nanotechnology approach. 5th Annual Personalized NanoMedicine Symposium, November 1-2, 2018. Miami, FL.
· Sneham Tiwari, Adriana Yndart, Venkata Atluri, Rahul Dev Jayant, Ajeet Kaushik, Asahi Tomitaka, Madhavan Nair. Withaferin A is a neuroprotective agent: Studies towards neurocognitive disorders. 24th Scientific Conference of the Society on Neuroimmune Pharmacology. April 10-14, 2018, Chicago, Illinois, USA.
· Upal Roy, Vadym Drozd, Andriy Durygin, Jesse Rodriguez, Paul Barber, Venkata Atluri, Xiaohua Liu, Thomas G Voss, Jonathan C Abshier, Surendra Saxena, Madhavan Nair. Development of Nanodiamond-based anti-HIV drug delivery targeted to the Brain. 24th Scientific Conference of the Society on Neuroimmune Pharmacology. April 10-14, 2018, Chicago, Illinois, USA.
· Venkata Subba Rao Atluri, Sudheesh Pilakka-Kanthikeel, Gabriella Garcia, Rahul Dev Jayant, Vidya Sagar, Thangavel Samikkannu, Adriana Yndart & Madhavan Nair. Inflammasome Gene Expression and their role in HIV and Cocaine-Induced Apoptosis. SNIP 23rd Scientific Conference, 2017, Philadelphia, USA.
· Nikkhah-Moshaie, Roozbeh., Kaushik, A., Sinha, R., Bhardwaj, V., Atluri, V., Jayant, R.D., Yndart, A., Pala, N., Nair, M. Nanoelectroporation of magneto-electric nanoparticles as drug nano-carriers into the brain cells. SNIP 23rd Scientific Conference, 2017, Philadelphia, USA.
· Sagar, VIDYA., Atluri, V.S.R., Tomitak, A., Nagasetti, A., Vashisit, A., Pilakka- Kanthikeel, S., El-Hage, N., McGoron, A., Nair, M. NIR-stimuli sensitive ‘smart’ magnetic nanoagent for on demand drug delivery. SNIP 23rd Scientific Conference, 2017, Philadelphia, USA.
· Thangavel, S., Atluri, VSR., Nair. Cocaine and HIV Upregulate Glycolytic Enzymes and Mitochondrial Biogenesis in Astrocytes. SNIP 23rd Scientific Conference, 2017, Philadelphia, USA.
· Vashist, Arti., Kaushik, Ajeet., Atluri, Venkata., Nikkhah-Moshaie, Roozbeh., Tomitaka, Asahi., Sagar, Vidya., Nair, Madhavan. Development of novel biopolymer based magnetic micro/nano hydrogels for targeted drug delivery and theranostic applications. SNIP 23rd Scientific Conference, 2017, Philadelphia, USA.
· Venkata Subba Rao Atluri, Rahul Dev Jayant, Sudheesh Pilakka Kanthikeel, Gabriella Garcia, Samikkannu Thangavel, Adriana Yndart, Ajeet Kaushik. Development of Tissue Inhibitor of Metalloproteinase-1 (TIMP- 1) Magnetic Nanoformulation for Regulation of Synaptic Plasticity in HIV-1 Infection. 9th Nanoflorida Symposium, Orlando.
· Venkata Atluri, Rahul Dev Jayant, Gabriella Garcia, Sudheesh Pilakka-Kanthikeel, Samikkannu Thangavel, Adriana Yndart, Ajeet Kaushik, Madhavan P.N. Nair. Development of Tissue Inhibitor of Metalloproteinase- 1 (TIMP-1) Magnetic Nanoformulation for Regulation of Synaptic Plasticity in HIV-1 Infection. International Journal of Nanomedicine. 3rd Personalized NanoMedicine Symposium, 2016, Miami, FL.
· Venkata Atluri, Melisa Hidalgo, Oscar Hernandez, Sudheesh Pilakka Kanthikeel, Kesava Rao, Samikkannu Thangavel, Vidya Sagar, Rahul Jayant, Adriana Yndart, Andrea Raymond, Marisela Agudelo, Ajeet Kaushik, Madhavan P.N. Nair. Role of Vorinostat in Regulation of Synaptic Plasticity Genes Expression in Nicotine Co treated HIV Infected Neurons. 2nd Personalized NanoMedicine Symposium, 2015, Miami, FL.
· Melissa Hidalgo, Venkata Atluri, Oscar Hernandez, Sudheesh Pilakka-Kanthikeel, Madhavan Nair. Dysregulation of synaptic plasticity in HIV infected Primary Neurons: Implication in HAND. 17th Annual Biomedical and Comparative Immunology symposium, 2015, at Miami, FL.
· Atluri, VSR., Hernandez, O., Hidalgo, M., Kurapati, KRV., Thangavel, S., PilakkaKanthikeel, S., Sagar, V., Yndart, A., Nair, M. Methamphetamine treatment and HIV-1 infection dysregulate Synaptic plasticity in SKNMC neuronal cells. 21st SNIP Conference, 2015 in Miami, FL, USA. J Neuroimmune Pharmacol (2015) 10(Suppl 2): S57–S112 DOI 10.1007/s11481-015-9596-y.
· Jayant, R.D., Atluri, V., Agudelo, M., Kaushik, A., Nair, M. Sustained Release NanoART Formulation for the Treatment of NeuroAIDS. 21st SNIP Conference, 2015 in Miami, FL, USA. J Neuroimmune Pharmacol (2015) 10(Suppl 2): S57–S112 DOI 10.1007/s11481-015-9596-y.
· Kauhsik, A., Jayant, RD., Roy, U., Huang, Z., Ruiz, A., Yndart, A., Sagar, V., Atluri, V., Nikkhah, R., Bharadwaj, V., Nair, M. In vitro & In-vivo Cytotoxic Evaluation of Magneto-Electric Nanoparticles for the CNS Delivery. 21st SNIP Conference, 2015 in Miami, FL, USA. J Neuroimmune Pharmacol (2015) 10(Suppl 2): S57–S112 DOI 10.1007/s11481-015-9596-y.
· Kurapati, VKR., Ssmikkannu, T., Atluri, VSR., Yndart, A., Nair, MPN. β -Amyloid, HIV-1 Infection and Drugs of Abuse Induced Neurodegeneration and Protective Effects of Ashwagandha. 21st SNIP Conference, 2015 in Miami, FL, USA. J Neuroimmune Pharmacol (2015) 10(Suppl 2): S57–S112 DOI 10.1007/s11481- 015-9596-y.
· Pilakka-Kanthikeel, S., Raymond, A., Atluri, VSR., Sagar, V., Nair, M. MicroRNA-155 regulates SAMHD1 facilitated HIV restriction in astrocyte. 21st SNIP Conference, 2015 in Miami, FL, USA. J Neuroimmune Pharmacol (2015) 10(Suppl 2): S57–S112 DOI 10.1007/s11481-015-9596-y.
· Roy, U., DIng, H., Huang, Z., Kaushik, A., Jayant, R., Kanthikeel, S., Raymond, A., Sagar, V., Yndart- Arias, A., Atluri, V., Nair, M.P. Characterization of on Demand Delivery of Fluorescent Magnetic Nanoparticle (MNP) Targeted Towards the Brain. 21st SNIP Conference, 2015 in Miami, FL, USA. J Neuroimmune Pharmacol (2015) 10(Suppl 2): S57–S112 DOI 10.1007/s11481-015-9596-y.
· Sagar, Vidya., Huang, Z., Kaushik, A., Roy, U., Jayant., R.D., Atluri, V.S.R., Pilakka-Kanthikeel, S., El Hage, N., Nair, M. Effect of Magneto-electric nanoparticle on deep brain motor coordination activity. 21st SNIP Conference, 2015 in Miami, FL, USA. J Neuroimmune Pharmacol (2015) 10(Suppl 2): S57–S112 DOI 10.1007/s11481-015-9596-y.
· hangavel, S., Rao, KVK., Agudelo, M., Atluri, VSR., Mulet, C., Nair, MP. HIV and Morphine: Oxidative Stress Impact Cell Cycle Regulation and Neurodegeneration. 21st SNIP Conference, 2015 in Miami, FL, USA. J Neuroimmune Pharmacol (2015) 10(Suppl 2): S57–S112 DOI 10.1007/s11481-015-9596-y.
· Atluri, VSR., Pilakka Kanthikeel, S., Rao, KVK., Sagar, V., Thangavel, S., Ding, H., Roy, U., Jayant, R., Yndart, A., Raymond, A., Agudelo, M., Hernandez, O.,Fuenmayor, M., Nair, M. Role of HDAC2 and miR- 485 in regulation of synaptic plasticity genes in HIV infection: Implication in HAND. 20th SNIP Conference, 2014 in New Orleans, Louisiana, USA. J Neuroimmune Pharmacol (2014) 9:3-64.
· Sagar, V., Plakka-Kanthikeel, S., Ding, H., Atluri, V.S.R., Jayant, R.D., Kaushik, A., Nair, M. Novel magneto-electric nano delivery of “microRNA mimic” across the blood-brain barrier: Implications to cocaine modulation on HIV-associated neurocognitive disorders. 20th SNIP Conference, 2014 in New Orleans, Louisiana, USA. J Neuroimmune Pharmacol (2014) 9:3-64.
· Agudelo, M., Yndart, A., Figueroa, Muñoz, K., Atluri, V.S.R., Thangavel, S., Nair, M. Cannabinoid Agonists Regulate Alcohol-induced Inflammation in Human Dendritic Cells. 20th SNIP Conference, 2014 in New Orleans, Louisiana, USA. J Neuroimmune Pharmacol (2014) 9:3-64.
· Ding, Hong., Yatfung, Chiu., Raymond, Andrea., Atluri, Venkata., Roy, Upal., Yndart-Arias, Adriana., Pilakka Kanthikeel, Sudheesh., Sagar, Vidya., Thangavel, Samikkannu, Nair, Madhavan. Development of hybrid nanocarrier (Au/Fe3O4) for active drug delivery to the brain to eliminate HIV-1 persistence. 20th SNIP Conference, 2014 in New Orleans, Louisiana, USA. J Neuroimmune Pharmacol (2014) 9:3-64.
· Kurapati, KRV., Thangavel, S., Atluri, VSR., Yndart, A., Nair, MPN. Ashwagandha (Withania somnifera) reverses HIV-1 induced neurodegeneration via attenuation of β-Amyloid plaques: Implications in HIV- Associated Neurocognitive Disorders (HAND). 20th SNIP Conference, 2014 in New Orleans, Louisiana, USA. J Neuroimmune Pharmacol (2014) 9:3-64.
· Pilakka Kanthikeel, S., Raymond, A., Atluri, VSR., Sagar, V., Roy, U., Yndart, A., Nair, M. SAMHD1 facilitates HIV-1 persistence: Role of miR-155. 20th SNIP Conference, 2014 in New Orleans, Louisiana, USA. J Neuroimmune Pharmacol (2014) 9:3-64.
· Roy, Upal., Ding, H., Kanthikeel, SP., Raymond, A., Atluri, V., Yndart-Arias, A., Munoz-Caamano, K., Sagar, V., Thangavel, S., Nair, M. Magnetic nanoparticle for targetted anti-hiv drug delivery in in vivo model. 20th SNIP Conference, 2014 in New Orleans, Louisiana, USA. J Neuroimmune Pharmacol (2014) 9:3-64.
· Thangavel, S., Rao, KVK., Ding, H., Agudelo, M., Atluri, VSR., Raymond, A., Perez, S., Kasturia, N., Nair, MP. Immunopathogenesis of HIV-1 Infection in Cocaine users: Role of Arachidonic Acid. 20th SNIP Conference, 2014 in New Orleans, Louisiana, USA. J Neuroimmune Pharmacol (2014) 9:3-64.
· Yndart, A., Agudelo, M., Raymond, A., Atluri, VSR., Munoz-Caamano, K., Pilakka Kanthikeel, S., Sagar, V., Nair, M. Bath salts alter synaptic plasticity gene expression in neurons. 20th SNIP Conference, 2014 in New Orleans, Louisiana, USA. J Neuroimmune Pharmacol (2014) 9:3-64. J Neuroimmune Pharmacol (2013) 8:371-444.
· Atluri, VSR, Sudheesh, PK, Samikkannu, T, Vijaya, P, Ding, H, Raymond, AD, Nair, M. Effect of nicotine on synaptic plasticity gene expression in HIV-1 infection: implication in HAND. 19th SNIP conference, 2013 in Puerto Rico, USA. J Neuroimmune Pharmacol (2013) 8:371-444.
· Kurapati, V.K.R, Atluri, V.S.R, Samikkannu, T, Yndart, A.A, Nair, M.P.N. Ashwagandha (Withania somnifera) reverses β-amyloid induced neuronal toxicity: Implications in HAND. SNIP 19th Scientific Conference, April 3-6, 2013, San Juan, Puerto Rico, USA. J Neuroimmune Pharmacol (2013) 8:371-444.
· Hong Ding, Marisela Agudelo, Sudheesh Pilakka Kanthikeel, Rakesh Guduru, Vidya Sagar, Venkata Atluri, Samikkannu Thangavel, Madhavan P. Nair. Dual Mechanism Enhanced Blood-Brain-Barrier Crossing by Transferrin conjugated Fluorescent Magnetic Liposome. SNIP 19th Scientific Conference, April 3-6, 2013, San Juan, Puerto Rico, USA. J Neuroimmune Pharmacol (2013) 8:371-444.
· Pilakka-Kanthikeel, S., Raymond, A., Atluri, V., Nair, M. Cocaine downregulates SAHMD1 expression and facilitates HIV-1 infection in astrocytes. SNIP 19th Scientific Conference, April 3-6, 2013, San Juan, Puerto Rico, USA. J Neuroimmune Pharmacol (2013) 8:371-444.
· Sagar, Vidya., Pilakka_kanthikeel, S.K., Priestap, H., Atluri, V.S.R., Ding, H., Guduru, R., Khizroev, S., Nair, M.P. Magnetic-Nanoformulation of M-opioid receptor antagonist (CTOP) for treatment of morphine-induced neuropathogenesis in HIV infection. SNIP 19th Scientific Conference, April 3-6, 2013, San Juan, Puerto Rico, USA. J Neuroimmune Pharmacol (2013) 8:371-444.
· Thangavel, S, Rao, K.V.K, Raymond, A, Ding, H, Atluri, V.S.R, Nair, M.P. Immunopathogenic mechanisms of HIV-1 clade B and C: Role of dopaminergic system. 19th SNIP conference, 2013 in Puerto Rico, USA. J Neuroimmune Pharmacol (2013) 8:371-444.
· Sudheesh Pilakka-Kanthikeel, Venkata Subba Rao Atluri and Madhavan Nair. Brain-derived neurotrophic factor delivery across the blood-brain barrier using magnetic nanocarriers for neuro-protection: an in vitro study. Nanoflorida, Sept 2012, Tampa-FL.
· Raymond A.D., Agudelo, M., Yndart, A., Atluri, V., Pilakka, S., Pichili, V., Hong, D., Sagar, V., Thangavel, S., Rao, K.V.K, Powell M.D., and Nair, M. Morphine and exosomal HIV-1 Nef: Potential roles in NeuroAIDS development. Health disparity Conference, July 11th-13th, 2012 at Univ. of North Texas, USA.
· Venkata Subba Rao Atluri, Sudheesh Pilakka Kanthikeel, Madhavan P.N. Nair. Differential effects of HIV 1B and HIV-1C infection on Synaptic plasticity genes: Implication in HIV associated neurocognitive disorders. Presented in a young investigators' poster presentation at 18th SNIP Conference, April 25-28, 2012 at Honolulu, Hawaii, USA. J Neuroimmune Pharmacol (2012) 7 (Suppl 1): S5-S81.
· Goutam Mandal, Venkata Subba Rao Atluri, Anthony Franco, Martin Wiese, Barbara Papadopoulou, Hiranmoy Bhattacharjee, Rita Mukhopadhyay. Regulation of Leishmania aquaglyceroporin, 2010. XXI Molecular Parasitology Meeting (MPM), 12-16 September 2010, held at Woods Hole, Massachusetts, USA.
· Rita Mukhopadhyay., Yao Zhou., Goutam Mandal., Venkata Subba Rao Atluri., Katherine Figarella., Nestor Uzcategui., Eric Beitz, and Hiranmoy Bhattacharjee. Alanine 163 in loop C of Leishmania major aquaglyceroporin LmAQP1 resides near the pore mouth of the channel and is critical for function. 14th International Congress on Infectious Diseases held on March 9-12, 2010 in Miami, FL, USA. International Journal of Infectious Diseases, Volume 14, Supplement 1, March 2010, Page e442. doi: 10.1016/j.ijid.2010.02.601.
· A.V. Subba Rao, Singhi P, Khandelwal N, Malla N. Two-dimensional gel electrophoresis analysis of T. solium cysticerci Lower Molecular Mass (10-30 kDa) antigens for the serodiagnosis of neurocysticercosis in children. 14th International Congress on Infectious Diseases held on March 9-12, 2010 at Miami, FL, USA. International Journal of Infectious Diseases, Volume 14, Supplement 1, March 2010, Pages e289-e290. doi: 10.1016/j.ijid.2010.02.2128.
· A.V. Subba Rao, Singhi P, Khandelwal N, Malla N. Evaluation of Lower Molecular Mass (10-30KDa) T. solium cysticerci antigen by Western blotting for the diagnosis of neurocysticercosis in children: Presented at the 13th International Congress on Infectious Diseases, Kuala Lumpur, Malaysia- June 19-22, 2008. International Journal of Infectious Diseases, Volume 12, Supplement 1, December 2008, Pages e393-e394. doi: 10.1016/j.ijid.2008.05.1039.
· A.V. Subba Rao, Singhi P, Khandelwal N, Malla N. Serodiagnosis of Neurocysticercosis in Children with the Use of T. solium cysticerci Excretory Secretory Antigens by ELISA and Immunoblotting: Presented at the 13th International Congress on Infectious Diseases, Kuala Lumpur, Malaysia- June 19-22, 2008. International Journal of Infectious Diseases, Volume 12, Supplement 1, December 2008, Page e394. doi: 10.1016/j.ijid.2008.05.1040.
· A.V. Subba Rao, et al., Evaluation of Crude Soluble Extract, Lower Molecular Weight (10-30KDa) and Excretory Secretory antigens of T. solium Cysticerci by ELISA for the diagnosis of neurocysticercosis in children: Presented at The Royal Society of Tropical Medicine and Hygiene One hundred years of Tropical Medicine: Meeting the millennium development goals, 13-15th September 2007, London, UK.
Research Grants:
Principal Investigator:
· 2022-2024: Therapeutic use of NLRP3 Inflammasome and caspase-1 inhibitors to prevent neuropathology in Alzheimer’s disease. Faculty Research Grant, NOORDA COM, Provo, Utah. Grant: $50,000
· 2021-20222: CRISPR/CAS9- technology to eradicate HIV-1 reservoirs in the brain and associated neurocognitive disorders. Faculty Research Grant, NOORDA COM, Provo, Utah. Grant: $25,000
· 2020-2021: Targeting neuroinflammation and epigenetic modifications in Alzheimer’s disease: A novel nanotechnology approach, FIU 2020 Faculty Grantsmanship Award.
· 2017-2021: Therapeutic Effect of Withaferin A and miR-Chimera on Alzheimer's Disease Cell Culture Models. HWCOM-FIU Pilot Grant.
Co-Principal Investigator:
· 2018-2022: Therapeutic role of Withaferin A and CRID3 in the prevention of Alzheimer’s disease Associated Neuropathology. Funding Agency: Florida Department of Health. PI: Dr. M Nair.
Co-Investigator:
· NIH R01 Grant: Targeting Inflammasome with stable endocannabinoid ligand AMG315: CRISPR/Cas9 and nanotechnology study in the context of HIV and cannabinoid. National Institute of Health (NIH)- R01DA052271. PI: Dr. Madhavan Nair.
· NIH R01 Grant: Multifunctional Nanocarrier to Eradicate HIV from latently infected CNS cells. National Institute of Health (NIH)-R01DA037838. PI: Dr. Madhavan Nair.
· NIH R01 Grant: Nanotechnology-Based Gene Editing to Eradicate HIV Brain Reservoir in Drug Abusers. Funding Agency: National Institute of Health (NIH)- R01DA042706. PI: Dr. Madhavan Nair.
· NIH R01 Grant: Nano-delivery of methanandamide across BBB to block cannabinoid-induced effects in HIV-1 infection. Funding Agency: National Institute of Health (NIH)- R01DA040537. PI: Dr. Madhavan Nair.
· NIH R01 Grant: Cocaine in the Neuropathogenesis of HIV infection: Role of HDAC2. Funding Agency: National Institute of Health (NIH)- R01DA034547. PI: Dr. Madhavan Nair.
· NIH R37 Grant: Role of Cocaine in Neuro-AIDS by HIV 1B and C Clades. Funding Agency: National Institute of Health (NIH)- R37DA025576. PI: Dr. Madhavan Nair.
· NIH R21 Grant: Novel Magneto-Electric Nanodelivery of Drugs to Eradicate HIV from CNS. Funding Agency: National Institute of Health (NIH)- R21MH101025. PI: Dr. Madhavan Nair.
· NIH R01 Grant: Polydrug Nanocarrier to Treat Opiate Addiction and HIV Disease. Funding Agency: National Institute of Health (NIH)- R01DA027049. PI: Dr. Madhavan Nair.
· NIH R01 Grant: Mechanisms of Neuro-AIDS by HIV1B and C Clades. Funding Agency: National Institute of Health (NIH)- R01MH085259. PI: Dr. Madhavan Nair.